什麼是 N-乙醯-L-蛋胺酸?

synonyms

  • N-Acetyl-L-methionine
  • 65-82-7
  • N-Acetylmethionine
  • Acetyl-L-methionine
  • Methionamine
  • N-acetyl-L-methionine
  • 65-82-7
  • N-acetylmethionine
  • Acetyl-L-Methionine
  • Methylthiamine

Molecular formula

C7H13NO3S

melting point

105.5℃

storage

powder

-20°C 3 years
4°C 2 years

in solvent

-80°C 2 years
-20°C 1 year

code

  • DSSTox substance ID DTXSID00883214
  • DSSTOX compound identifier DTXCID701022763
  • NSC number 118514
  • EC number 200-617-7
  • ECHA Substance Infocard ID 100.000.561
  • RxNorm ID 1426463
  • DrugBank ID 01646
  • Human Metabolome Database ID HMDB0011745
  • UNII 9J12WX5B6A
  • Probes And Drugs ID PD008892
  • KEGG ID C02712
  • PDB ligand ID AME
  • CAB ID 4494

describe

N-Acetyl-L-methionine is a derivative of L-methionine, which is L-methionine in which one of the amine hydrogens is replaced by an acetyl group. It has the function of nutritional supplement. It is N-acetyl-L-amino acid, L-methionine derivative and N-acetylmethionine. It is the conjugate acid of N-acetyl-L-methionine (1-). It is the enantiomer of N-acetyl-D-methionine.

N-acetyl-L-methionine is a metabolite found or produced in Escherichia coli (strain K12, MG1655).

N-acetyl-L-methionine is a natural product found in Arabidopsis thaliana, ginseng, and other organisms for which data are available.

N-acetyl-L-methionine is a human metabolite that is nutritionally and metabolically equivalent to L-methionine. L-methionine is an indispensable amino acid required for normal growth and development.

N-acetylmethionine is an amino acid used in the peritoneal dialysis treatment of patients with renal failure and in the nutritional therapy of patients with nutritional deficiencies or debility following infection.

N-acetyl-L-methionine is an excellent protector of human serum albumin against post-translational oxidation

Research shows that N- AcMet , N-acetyl-L-methionine is excellent at scavenging reactive oxygen species and protecting proteins from oxidation. N-AcMet has a good stabilizing effect on protein structure and its antioxidant properties. The reduction in oxidized recombinant human serum albumin (rHSA, Recombinant human serum albumin) burden helps maintain normal pharmacokinetics. Therefore, N-AcMet should be useful as a novel stabilizer and antioxidant for albumin and other solubilized protein preparations. It is expected that N-AcMet will be approved as a new stabilizer in the near future.

Review

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