噻菌靈 (噻苯唑/噻苯達唑)

Thiabendazole, also known as TBZ and under the trade names Mintezol, Tresaderm and Arbotect, is an antiseptic, antifungal and antiparasitic agent.

  • Chemical formula C10H7N3S
  • CAS No. 148-79-8

Who discovered thiabendazole?

In 1961, a Merck research team led by Dr. William Campbell discovered thiabendazole, the first drug known to kill the Trichinella parasite in sheep, goats, cattle and pigs.

use

preservative

Thiabendazole (TBZ) is a chemical fungicide and parasiticide mainly used in the food industry to prevent mildew and blight on vegetables and fruits during transportation and long-term storage. and other fungal diseases in fruits (such as oranges) and vegetables; it is also used as a preventive treatment for Dutch elm disease.

Thiabendazole is also used as a food additive, a preservative, E number E233. For example, it is applied to bananas to ensure freshness and is a common ingredient in the wax applied to the peels of citrus fruits. It is not approved as a food additive in the European Union, Australia and New Zealand.

Use has been reported in the treatment of aspergillosis.

It is also mixed with azoxystrobin for use in antifungal siding.

parasiticide

As an antiparasitic drug, thiabendazole controls roundworms (such as the roundworm that causes strongyloidiasis), hookworms, and other helminth species that infect wildlife, livestock, and humans.

Thiabendazole is used to treat infections caused by worms such as nematodes. Thiabendazole is also used to treat pinworms (when present along with nematodes), hookworms, whipworms, roundworms, and trichinellosis. Thiabendazole may also be used for purposes other than those listed in this Medication Guide.

other

In dogs and cats, thiabendazole is used to treat ear infections.

Thiabendazole is also a chelating agent, which means it is used medically to bind metals in cases of metal poisoning, such as lead, mercury, or antimony poisoning.

Research

Genes responsible for cell wall maintenance in yeast have been shown to be responsible for angiogenesis in vertebrates. Thiabendazole blocks angiogenesis in frog embryos and human cells. It has also been shown to act as a blood vessel disruptor to reduce the number of newly established blood vessels. Thiabendazole has been shown to work effectively in certain cancer cells.

pharmacodynamics

Thiabendazole acts by inhibiting the mitochondrial helminth-specific enzyme fumarate reductase and may interact with endogenous quinones.

safety

The substance appears to be slightly toxic at higher doses, causing effects such as liver and intestinal disease in test animals at high exposure levels (just below the LD50 level). Some reproductive impairment and reduced weaning weight were also observed at high exposure. Effects in humans when used as a medicine include nausea, vomiting, loss of appetite, diarrhea, dizziness, drowsiness, or headache; and in rare cases, tinnitus, vision changes, stomach pain, yellowing of the eyes and skin, dark urine, fever, Fatigue, increased thirst, and changes in urine output. Carcinogenic effects have been shown at high doses.

Is Thiabendazole an over-the-counter drug?

Thiabendazole 10% Topical Cream is a prescription medication dispensed via a pump mechanism for easy, controlled use.

Review

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