鹽酸硫胺素-用途,副作用等

What is thiamine hydrochloride?

Thiamine hydrochloride injections are a form of vitamin B1 and are effective in treating thiamine deficiency or beriberi, whether dry beriberi (a major symptom related to the nervous system) or wet beriberi (related to the cardiovascular system) main symptoms). Thiamine hydrochloride injection is suitable for situations where rapid restoration of thiamine is required, such as Wernicke's encephalopathy, acute collapse of infantile beriberi, cardiovascular disease caused by thiamine deficiency, and neuritis during pregnancy (severe vomiting). This is also required when administering intravenous (IV) glucose to individuals with borderline thiamine status to avoid precipitation of heart failure.

Thiamine hydrochloride injection is also suitable for patients who have been diagnosed with thiamine deficiency and are unable to take oral thiamine due to severe anorexia, nausea, vomiting or malabsorption.

What are the side effects of thiamine hydrochloride?

Side effects of thiamine hydrochloride include:

  • warmth,
  • itching,
  • measles,
  • weakness,
  • sweat,
  • nausea,
  • Restless,
  • Throat is tight,
  • swelling under the skin,
  • Skin turns blue (cyanosis),
  • Pulmonary Edema,
  • gastrointestinal bleeding gastrointestinal tract, and
  • allergic reaction.

Thiamine hydrochloride dosage

When treating beriberi, give 10 to 20 mg of thiamine hydrochloride intramuscularly (IM) three times daily for up to two weeks. It is recommended to take an oral therapeutic multivitamin preparation containing 5 to 10 mg of thiamine daily for one month to saturate body tissues.

Mild infantile beriberi may respond to oral treatment, but if collapse occurs, intravenous doses of 25 mg may be used with caution.

Patients with neuritis of pregnancy whose vomiting is too severe for adequate oral therapy should receive 5 to 10 mg of thiamine hydrochloride intramuscularly daily.

In the treatment of Wernicke-Korsakoff syndrome, thiamine hydrochloride is given as an initial dose of 100 mg intravenously, followed by 50 to 100 mg intramuscularly daily until the patient is on a regular, balanced diet.

Patients with borderline thiamine status receiving glucose should be given 100 mg of thiamine hydrochloride each time in the first few liters of intravenous fluid to avoid precipitating heart failure.

Thiamine hydrochloride for children

Thiamine hydrochloride should be given to children under 12 years of age only on expert advice.

What drugs, substances, or supplements may interact with thiamine hydrochloride?

Thiamine hydrochloride may interact with other medications.

Tell your doctor about all the medicines and supplements you use.

Thiamine Hydrochloride During Pregnancy and Breastfeeding

If you are pregnant or plan to become pregnant, tell your doctor before using thiamine hydrochloride; harm to the fetus is not expected, but it should be used during pregnancy only if clearly needed. It is not known whether thiamine hydrochloride passes into breast milk. Please consult your doctor before breastfeeding.

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