Benfotiamine , also known as rINN or S-benfotiamine O-monophosphate , is a synthetic derivative of thiamine (vitamin B1). Thiamine is water-soluble and is easily excreted from the body, while benfotiamine is more fat-soluble, allowing for better absorption and retention in tissues. It is commonly used as a dietary supplement to increase thiamine levels in the body.
In Japan during the 1950s and 1960s, as beriberi was a common health problem in Japan, several lipophilic analogues were synthesized, including furthiamine, sulbutiamine, and benfotiamine.
Here are some key points about benfotiamine:
Thiamine metabolism:
Thiamine is an essential B vitamin that plays a vital role in energy metabolism. It is involved in the conversion of carbohydrates into energy and is important for the proper functioning of the nervous system.
Increase bioavailability:
Benfotiamine is thought to have better bioavailability than thiamine's traditional form, thiamine hydrochloride. This increased lipid solubility allows benfotiamine to penetrate cell membranes more efficiently.
Antioxidant properties:
Benfotiamine is thought to have antioxidant properties. Antioxidants help neutralize harmful free radicals in the body, which are linked to various health problems.
Diabetes and neuropathy:
Several studies have examined the potential benefits of benfotiamine for diabetes and diabetic neuropathy. Diabetic neuropathy is a type of nerve damage that can occur in people with diabetes.
inflammation:
There is some evidence that benfotiamine may have anti-inflammatory effects, which may be beneficial for certain health conditions associated with chronic inflammation.
Peripheral neuropathy:
Benfotiamine has been studied for its potential role in treating peripheral neuropathy, a type of nerve damage often associated with conditions such as diabetes.
Eye health:
Several studies have explored the potential benefits of benfotiamine in supporting eye health, particularly in relation to diabetic retinopathy.
Dosage and Supplementation:
The appropriate dosage of benfotiamine may vary and must follow recommended guidelines provided by your healthcare professional. Benfotiamine is usually taken as a dietary supplement.
Safety and Side Effects:
Benfotiamine is generally considered safe when taken within recommended doses. However, as with any supplement, it may cause side effects in some people. It is important to consult a healthcare professional before starting any supplements, especially for people with existing medical conditions or who are taking other medications.
As with any supplement, individual reactions may vary, so it is important to consult a healthcare professional for personalized advice based on an individual's health and medical history.
