噻菌靈 (噻苯唑/噻苯達唑)

Thiabendazole, also known as TBZ and under the trade names Mintezol, Tresaderm and Arbotect, is an antiseptic, antifungal and antiparasitic agent.

  • Chemical formula C10H7N3S
  • CAS No. 148-79-8

Who discovered thiabendazole?

In 1961, a Merck research team led by Dr. William Campbell discovered thiabendazole, the first drug known to kill the Trichinella parasite in sheep, goats, cattle and pigs.

use

preservative

Thiabendazole (TBZ) is a chemical fungicide and parasiticide mainly used in the food industry to prevent mildew and blight on vegetables and fruits during transportation and long-term storage. and other fungal diseases in fruits (such as oranges) and vegetables; it is also used as a preventive treatment for Dutch elm disease.

Thiabendazole is also used as a food additive, a preservative, E number E233. For example, it is applied to bananas to ensure freshness and is a common ingredient in the wax applied to the peels of citrus fruits. It is not approved as a food additive in the European Union, Australia and New Zealand.

Use has been reported in the treatment of aspergillosis.

It is also mixed with azoxystrobin for use in antifungal siding.

parasiticide

As an antiparasitic drug, thiabendazole controls roundworms (such as the roundworm that causes strongyloidiasis), hookworms, and other helminth species that infect wildlife, livestock, and humans.

Thiabendazole is used to treat infections caused by worms such as nematodes. Thiabendazole is also used to treat pinworms (when present along with nematodes), hookworms, whipworms, roundworms, and trichinellosis. Thiabendazole may also be used for purposes other than those listed in this Medication Guide.

other

In dogs and cats, thiabendazole is used to treat ear infections.

Thiabendazole is also a chelating agent, which means it is used medically to bind metals in cases of metal poisoning, such as lead, mercury, or antimony poisoning.

Research

Genes responsible for cell wall maintenance in yeast have been shown to be responsible for angiogenesis in vertebrates. Thiabendazole blocks angiogenesis in frog embryos and human cells. It has also been shown to act as a blood vessel disruptor to reduce the number of newly established blood vessels. Thiabendazole has been shown to work effectively in certain cancer cells.

pharmacodynamics

Thiabendazole acts by inhibiting the mitochondrial helminth-specific enzyme fumarate reductase and may interact with endogenous quinones.

safety

The substance appears to be slightly toxic at higher doses, causing effects such as liver and intestinal disease in test animals at high exposure levels (just below the LD50 level). Some reproductive impairment and reduced weaning weight were also observed at high exposure. Effects in humans when used as a medicine include nausea, vomiting, loss of appetite, diarrhea, dizziness, drowsiness, or headache; and in rare cases, tinnitus, vision changes, stomach pain, yellowing of the eyes and skin, dark urine, fever, Fatigue, increased thirst, and changes in urine output. Carcinogenic effects have been shown at high doses.

Is Thiabendazole an over-the-counter drug?

Thiabendazole 10% Topical Cream is a prescription medication dispensed via a pump mechanism for easy, controlled use.

Review

All comments are moderated before being published

HealthyPIG Magazine

View all
牛骨湯食譜大全|Instant Pot 壓力煲 & 傳統老火湯版本

牛骨湯食譜大全|Instant Pot 壓力煲 & 傳統老火湯版本

牛骨湯食譜係香港家庭常見嘅煲湯之一,牛骨湯香濃滋補,配合中藥材更具養生功效。本文介紹肉骨類選擇、牛骨湯建議配搭、常見中藥材分類,以及Instant Pot壓力煲與傳統老火湯版本食譜,並引用科學研究支持。
澳洲飲用水發現「食腦變形蟲」:全球風險與地區對策(含各國/各州實用指南)

澳洲飲用水發現「食腦變形蟲」:全球風險與地區對策(含各國/各州實用指南)

澳洲飲用水發現「食腦變形蟲」:全球風險與地區對策(含各國/各州實用指南) 澳洲飲用水發現「食腦變形蟲」:全球風險與地區對策(含各國/各州實用指南) 重點:事件本身不代表飲水會感染;主要風險來自水經鼻腔進入。 目錄 ...
如何判斷雞翅是否變壞?

如何判斷雞翅是否變壞?

重點摘要 雞翅會變質嗎? 如何判斷雞翅是否變壞? 過期雞翅還能食嗎? 雞翅可存放多久? 如何儲存雞翅? 雞翅可以冷凍嗎? 結論 雞翅會變質嗎? 會。皮脂較多、表面不潔或溫度過高時,細菌繁殖更快。 如何判斷雞翅是否變壞? 外觀:皮色發黃、出黑斑或血水。 觸感:表面黏滑、軟爛。 氣...
如何判斷雞蛋是否變壞?

如何判斷雞蛋是否變壞?

重點摘要 雞蛋會變質嗎? 如何判斷雞蛋是否變壞? 過期雞蛋還能食嗎? 雞蛋可存放多久? 如何儲存雞蛋? 雞蛋可以冷凍嗎? 結論 雞蛋會變質嗎? 會。殼面有微孔,溫差及濕度變化會令細菌入侵。 如何判斷雞蛋是否變壞? 水測:沉底=較新鮮;浮起=多半變壞。 打開觀察:蛋白渾濁水樣、蛋黃...
如何判斷羊肉是否變壞?

如何判斷羊肉是否變壞?

重點摘要 羊肉會變質嗎? 如何判斷羊肉是否變壞? 過期羊肉還能食嗎? 羊肉可存放多久? 如何儲存羊肉? 羊肉可以冷凍嗎? 結論 羊肉會變質嗎? 會。脂肪多而易氧化,處理或存放唔好就會變壞。 如何判斷羊肉是否變壞? 顏色:紅轉黑,或出現綠斑。 脂肪:由白轉黃兼有酸味。 氣味:由輕...
如何判斷豬肉是否變壞?

如何判斷豬肉是否變壞?

重點摘要 豬肉會變質嗎? 如何判斷豬肉是否變壞? 過期豬肉還能食嗎? 豬肉可存放多久? 如何儲存豬肉? 豬肉可以冷凍嗎? 結論 豬肉會變質嗎? 會。豬肉表面水活度高,加上處理不潔或溫度過高,容易腐敗。 如何判斷豬肉是否變壞? 顏色:粉紅轉灰、發綠或出斑。 氣味:酸臭、腥臭味濃 ...
如何判斷牛肉是否變壞?

如何判斷牛肉是否變壞?

重點摘要 牛肉會變質嗎? 如何判斷牛肉是否變壞? 過期牛肉還能食嗎? 牛肉可存放多久? 如何儲存牛肉? 牛肉可以冷凍嗎? 結論 牛肉會變質嗎? 會。牛肉含高蛋白同水分,若溫度控制或衛生不當,細菌會快速繁殖,導致變壞。 如何判斷牛肉是否變壞? 顏色:鮮紅轉深褐甚至發黑;脂肪變黃。 ...
成年後懷疑自己有注意力不足過動症(ADHD),應該接受診斷嗎?

成年後懷疑自己有注意力不足過動症(ADHD),應該接受診斷嗎?

在過去,注意力不足過動症(Attention-Deficit/Hyperactivity Disorder, ADHD)多被視為「小孩的病」,很多成年人小時候從未被評估或診斷。直到近年社會對心理健康重視度提升,許多成人才開始懷疑,自己長期以來的專注困難、健忘、衝動或時間管理不良,可能與 ADHD 有關。這種「晚發現」的情況相當普遍,也引發了問題:成年後是否值得接受 ADHD 診斷?

哪些職業對健康影響最大?科學與現實的分析

哪些職業對健康影響最大?科學與現實的分析

在現代社會中,工作佔據了人們生命中相當大的一部分。然而,不同職業對健康的風險並不相同。一些工作性質或環境,會顯著增加慢性病、心理壓力、甚至縮短壽命的風險。以下從科學研究與醫學角度,探討幾類對健康損害較大的職業,並附上相關統計數據。