CoQ10 - 泛醇與泛醌

Ubiquinol outperforms ubiquinone in enhancing CoQ10 status in older men

Coenzyme Q10 (CoQ10) exerts its functions in the body through the ability of its benzoquinone head group to accept and donate electrons. The main function is to transfer electrons in the electron transport chain to produce ATP and serve as an important lipophilic antioxidant.

Ubiquinone is the oxidized form of CoQ10, often formulated in commercial supplements, and must be reduced to ubiquinol after consumption in order for CoQ10 to function. So whether ubiquinol is more effective at enhancing CoQ10 status in older men than ubiquinone.

For older men, ubiquinol appears to be a better supplement form than ubiquinone for enhancing CoQ10 status. Neither ubiquinol nor ubiquinone supplementation affected measured oxidative stress biomarkers.

Difference Between Ubiquinol and Ubiquinone

Ubiquinol and ubiquinone are both forms of CoQ10 (coenzyme Q10), an antioxidant commonly used to support fertility, heart health, and overall health. Antioxidants are essential for protecting the body's cells from free radicals and oxidative stress, which can lead to chronic disease and damage sperm health.

From a chemical perspective, the main difference between ubiquinol and ubiquinone is that ubiquinol is the reduced form of CoQ10, while ubiquinone is the oxidized form. This means that ubiquinone has more electrons than ubiquinol. But does this small—like microscopic—difference really change how they operate?

CoQ10 is naturally produced in the body and helps all cells produce energy; it is highest in organs with high metabolic rates, such as the heart, kidneys, spleen and liver. In the body, CoQ10 molecules actually switch back and forth between oxidized and reduced forms. Both ubiquinol and ubiquinone supplements are safe, and studies show they function similarly in the body.

Is ubiquinol better than ubiquinone?

Some researchers hypothesize that ubiquinol is more "bioavailable." Bioavailability is a term that refers to the ability of a drug or other substance to be absorbed and utilized by the body. In a 2018 study of older men, two weeks of ubiquinol supplementation increased CoQ10 activity compared to ubiquinone supplementation. However, research results have been mixed.

A 2020 study found no statistically significant difference in bioavailability between ubiquinol and ubiquinone. Even when ingested as ubiquinone, CoQ10 appears almost exclusively in the blood as ubiquinone, indicating the body's ability to convert the coenzyme into its most efficient form.

Another 2019 study showed that the type of supplement is actually more important than the form of CoQ10 when it comes to bioavailability. After testing seven different supplements, researchers found that softgel capsules containing either ubiquinone or ubiquinol were the most effective.

Considering these studies, there is no strong evidence that ubiquinol is better when taken in supplement form.

There is no statistically significant difference in bioavailability between ubiquinol and ubiquinone. Even when ingested as ubiquinone, CoQ10 appears almost exclusively as ubiquinol in the blood, indicating the body's ability to convert the antioxidant into its most effective form.

Benefits of Ubiquinone CoQ10

One noteworthy thing about ubiquinone CoQ10 is its history. There have been thousands of clinical trials using ubiquinone CoQ10, including fertility studies and heart health studies, but there have been very few clinical trials using ubiquinone. (This does not mean that ubiquinol is less effective. Studies show that when comparing ubiquinol to ubiquinone, they function similarly and are relatively bioavailable.)

Ubiquinone appears to be more stable and less expensive to make than ubiquinol.

Benefits of taking ubiquinone CoQ10 include:

  • Same absorption rate as panthenol
  • Safety backed by thousands of clinical trials
  • May enhance heart function, prevent migraines, support healthy skin, reduce fatigue, act as an antidepressant, reduce inflammation, and combat infertility in both men and women.

Using Ubiquinone CoQ10 to Promote Fertility

As mentioned above, CoQ10 is an antioxidant, a compound that protects body cells from free radicals and oxidative stress.

Free radicals are unstable molecules that are natural byproducts of everyday life, such as toxin exposure, disease, and poor lifestyle. If left unchecked, free radicals can cause damage to our cells. This damage is called "oxidative stress" and can be detrimental to sperm health.

Oxidative stress has been linked to male infertility and is present in 30-80% of cases of infertility. Men's sperm quality tends to decline with age; CoQ10 levels also decline with age, making high-energy functions like sperm development less efficient and more difficult. (CoQ10 levels in women can also decrease, which can also affect women's fertility.)

As early as 1997, researchers studied CoQ10's correlation with sperm health. Research shows that supplementing with CoQ10 as part of a healthy lifestyle can enhance fertility and may improve sperm concentration, motility (ability to swim) and morphology (size and shape of sperm). This research includes:

In a 2009 study, patients with reduced sperm motility were treated with 200 mg of CoQ10 daily for six months. Over the course of the study, antioxidant levels in patients' semen increased and sperm motility improved.
In a 2013 study, men with low sperm counts and poor motility/morphology also received 200 mg of CoQ10 daily for three months. The supplement group was associated with significant improvements in sperm morphology compared to the placebo group.
In a 2020 study that compiled data from three clinical trials of CoQ10, researchers found that CoQ10 supplementation had a profound impact on sperm motility over a period of 3-6 months.
Since many energy-dependent processes in sperm cells rely on the availability of CoQ10, many male fertility supplements contain ubiquinol or ubiquinone.

What type of CoQ10 does Legacy supplement contain?

Legacy's Sperm Health Coenzyme Q10 supplement contains ubiquinone, which is designed to enhance sperm concentration, motility and morphology. Legacy's supplement comes in a softgel form, which research shows is the most effective delivery form of CoQ10.

Each capsule contains 100 mg of CoQ10 antioxidants and healthy plant-based fats. This supplement is ideal for anyone who wants to enhance sperm health, is pregnant, or is considering freezing sperm.

Review

All comments are moderated before being published

HealthyPIG Magazine

View all
牛骨湯食譜大全|Instant Pot 壓力煲 & 傳統老火湯版本

牛骨湯食譜大全|Instant Pot 壓力煲 & 傳統老火湯版本

牛骨湯食譜係香港家庭常見嘅煲湯之一,牛骨湯香濃滋補,配合中藥材更具養生功效。本文介紹肉骨類選擇、牛骨湯建議配搭、常見中藥材分類,以及Instant Pot壓力煲與傳統老火湯版本食譜,並引用科學研究支持。
澳洲飲用水發現「食腦變形蟲」:全球風險與地區對策(含各國/各州實用指南)

澳洲飲用水發現「食腦變形蟲」:全球風險與地區對策(含各國/各州實用指南)

澳洲飲用水發現「食腦變形蟲」:全球風險與地區對策(含各國/各州實用指南) 澳洲飲用水發現「食腦變形蟲」:全球風險與地區對策(含各國/各州實用指南) 重點:事件本身不代表飲水會感染;主要風險來自水經鼻腔進入。 目錄 ...
如何判斷雞翅是否變壞?

如何判斷雞翅是否變壞?

重點摘要 雞翅會變質嗎? 如何判斷雞翅是否變壞? 過期雞翅還能食嗎? 雞翅可存放多久? 如何儲存雞翅? 雞翅可以冷凍嗎? 結論 雞翅會變質嗎? 會。皮脂較多、表面不潔或溫度過高時,細菌繁殖更快。 如何判斷雞翅是否變壞? 外觀:皮色發黃、出黑斑或血水。 觸感:表面黏滑、軟爛。 氣...
如何判斷雞蛋是否變壞?

如何判斷雞蛋是否變壞?

重點摘要 雞蛋會變質嗎? 如何判斷雞蛋是否變壞? 過期雞蛋還能食嗎? 雞蛋可存放多久? 如何儲存雞蛋? 雞蛋可以冷凍嗎? 結論 雞蛋會變質嗎? 會。殼面有微孔,溫差及濕度變化會令細菌入侵。 如何判斷雞蛋是否變壞? 水測:沉底=較新鮮;浮起=多半變壞。 打開觀察:蛋白渾濁水樣、蛋黃...
如何判斷羊肉是否變壞?

如何判斷羊肉是否變壞?

重點摘要 羊肉會變質嗎? 如何判斷羊肉是否變壞? 過期羊肉還能食嗎? 羊肉可存放多久? 如何儲存羊肉? 羊肉可以冷凍嗎? 結論 羊肉會變質嗎? 會。脂肪多而易氧化,處理或存放唔好就會變壞。 如何判斷羊肉是否變壞? 顏色:紅轉黑,或出現綠斑。 脂肪:由白轉黃兼有酸味。 氣味:由輕...
如何判斷豬肉是否變壞?

如何判斷豬肉是否變壞?

重點摘要 豬肉會變質嗎? 如何判斷豬肉是否變壞? 過期豬肉還能食嗎? 豬肉可存放多久? 如何儲存豬肉? 豬肉可以冷凍嗎? 結論 豬肉會變質嗎? 會。豬肉表面水活度高,加上處理不潔或溫度過高,容易腐敗。 如何判斷豬肉是否變壞? 顏色:粉紅轉灰、發綠或出斑。 氣味:酸臭、腥臭味濃 ...
如何判斷牛肉是否變壞?

如何判斷牛肉是否變壞?

重點摘要 牛肉會變質嗎? 如何判斷牛肉是否變壞? 過期牛肉還能食嗎? 牛肉可存放多久? 如何儲存牛肉? 牛肉可以冷凍嗎? 結論 牛肉會變質嗎? 會。牛肉含高蛋白同水分,若溫度控制或衛生不當,細菌會快速繁殖,導致變壞。 如何判斷牛肉是否變壞? 顏色:鮮紅轉深褐甚至發黑;脂肪變黃。 ...
成年後懷疑自己有注意力不足過動症(ADHD),應該接受診斷嗎?

成年後懷疑自己有注意力不足過動症(ADHD),應該接受診斷嗎?

在過去,注意力不足過動症(Attention-Deficit/Hyperactivity Disorder, ADHD)多被視為「小孩的病」,很多成年人小時候從未被評估或診斷。直到近年社會對心理健康重視度提升,許多成人才開始懷疑,自己長期以來的專注困難、健忘、衝動或時間管理不良,可能與 ADHD 有關。這種「晚發現」的情況相當普遍,也引發了問題:成年後是否值得接受 ADHD 診斷?

哪些職業對健康影響最大?科學與現實的分析

哪些職業對健康影響最大?科學與現實的分析

在現代社會中,工作佔據了人們生命中相當大的一部分。然而,不同職業對健康的風險並不相同。一些工作性質或環境,會顯著增加慢性病、心理壓力、甚至縮短壽命的風險。以下從科學研究與醫學角度,探討幾類對健康損害較大的職業,並附上相關統計數據。