Effects, Ingredients, and Clinical Research of Codaewon

Efficacy, Components, and Clinical Research of Codaewon

Codaewon is a cough suppressant and expectorant drug combining multiple active ingredients, produced by Daewon Pharm and distributed by Firma Vai Hong and HealthCare PharmaScience. This product is primarily used to treat phlegmy coughs and includes the following main ingredients:

• Dihydrocodeine bitartrate: An opioid analgesic with cough suppressant properties.
• Guaifenesin: An expectorant that helps to clear mucus.
• DL-Methylephedrine HCl: A sympathomimetic drug used to reduce airway resistance.
• Chlorpheniramine maleate: A first-generation antihistamine used to reduce allergic reactions.

Components and Mechanisms of Action Each Codaewon tablet contains:

• Dihydrocodeine bitartrate: 5 mg
• Guaifenesin: 50 mg
• DL-Methylephedrine HCl: 17.5 mg
• Chlorpheniramine maleate: 1.5 mg

These ingredients combined provide the following effects:

• Dihydrocodeine: As an opioid analgesic, it reduces coughing by inhibiting the central nervous system.
• Guaifenesin: As an expectorant, it helps to thin and expel mucus.
• Methylephedrine: A sympathomimetic drug that helps to dilate the bronchial tubes, alleviating breathing difficulties.
• Chlorpheniramine: An antihistamine that reduces symptoms caused by allergic reactions, such as nasal congestion and runny nose.

Indications Codaewon is primarily used to treat the following symptoms:

• Phlegmy coughs
• Increased mucus due to respiratory infections
• Bronchitis and acute bronchitis

Dosage and Administration Codaewon is available in oral tablets and syrup forms. It is recommended to take it after meals to reduce gastrointestinal side effects.

Adult Dosage:

• Tablets: Twice daily, two tablets each time.
• Syrup: Twice daily, 20 ml each time.

Children's Dosage (8-11 years):

• Tablets: Twice daily, one tablet each time.

Children's Dosage (11-15 years):

• Tablets: Twice daily, one to two tablets each time.

Side Effects Common side effects of Codaewon include:

• Drowsiness
• Dizziness
• Constipation
• Gastrointestinal discomfort
• Blurred vision
• Dry mouth

Long-term use may lead to tolerance or addiction, and discontinuation may result in severe withdrawal symptoms. If severe side effects occur, such as breathing difficulties, discontinue use and consult a doctor or pharmacist immediately.

Contraindications Patients should consult a doctor or pharmacist before using Codaewon, especially if they have the following conditions:

• Allergies to any ingredients
• History or presence of alcohol or drug dependence
• Respiratory distress, severe bronchial asthma, or gastrointestinal obstruction
• Pregnant or breastfeeding women
• Concurrent use of other antihistamines, sedatives, or blood pressure-lowering medications

It is recommended to avoid long-term use and increase fiber intake, water consumption, and physical activity to reduce constipation side effects. Avoid alcohol consumption during medication and refrain from activities requiring high mental concentration or operating machinery.

Precautions

• This product contains opioid ingredients, which may lead to addiction, and long-term use may develop drug tolerance.
• If abnormal symptoms occur, such as rash, nausea, or vomiting, discontinue use immediately and take appropriate measures.
• Avoid alcohol consumption during medication.
• Do not use in conjunction with other cough suppressants, expectorants, antihistamines, or sedatives.

Storage

• Tablets: Store in a dry and cool place, away from light.
• Syrup: Keep tightly sealed.

Clinical Research

Research Title: Efficacy and Safety of Codewon S Syrup in the Treatment of Acute Bronchitis: A Phase 3 Double-blind Randomised Control Trial
Authors: Lim Seong Yong, Kim Jooil, Yeon Eungtae, Kim Tae-bum, Kim Hak-ryul, Kim Do Jin, Yoo Kwang Ha, Shim Jae Jeong
Published in: Korean Academy of Tuberculosis and Respiratory Diseases, November 2020

Abstract: This study aimed to evaluate the efficacy and safety of Codewon S Syrup in treating acute bronchitis. Using a randomized, double-blind, placebo-controlled multicenter trial design, 204 acute bronchitis patients were divided into three groups: Cod-S (Codaewon S group), Dih-C (Dihydrocodeine group), and Pel-S (Pelargonium group). The primary endpoint was the change in total bronchitis severity score (BSS) from baseline to day 4 of treatment. Results showed that the BSS change in the Cod-S group was significantly higher than in the other two groups. The Cod-S group also demonstrated higher response rates, improvement rates, and patient satisfaction, with no significant adverse events observed.

Codewon S Syrup was more effective in improving acute bronchitis symptoms than dihydrocodeine or pelargonium.

Purchase Information In Hong Kong, Codaewon is a prescription drug and can only be purchased at pharmacies with a doctor's prescription. For more information, visit the website of the Hong Kong Department of Health's Drug Office.

Summary Codaewon is an effective cough suppressant and expectorant suitable for treating various respiratory symptoms. However, due to its potent ingredients, usage should strictly follow the guidance of doctors or pharmacists to avoid side effects and addiction risks. For more information or any questions, please consult professional healthcare providers.

References

1. Lim, S.Y., Kim, J., Yeon, E., Kim, T., Kim, H., Kim, D.J., Yoo, K.H., & Shim, J.J. (2020). Efficacy and Safety of Codewon S Syrup in the Treatment of Acute Bronchitis: A Phase 3 Double-blind Randomised Control Trial. Korean Academy of Tuberculosis and Respiratory Diseases.
2. Daewon Pharm. (2011). Codaewon Product Information.
3. Zhang, C. (2022). Introduction to Codaewon Medication.