EPA 二十碳五烯酸

Eicosapentaenoic acid (EPA) is one of several omega-3 fatty acids. It is found in cold-water fatty fish, such as salmon. It is also found in fish oil supplements, as well as docosahexaenoic acid (DHA).
Omega-3 fatty acids are part of a healthy diet and can help reduce the risk of heart disease. Consuming more EPA in the diet has positive effects on coronary heart disease, high triglycerides (fats in the blood), high blood pressure and inflammation.

EPA's work

EPA prevents blood from clotting easily. These fatty acids can also reduce pain and swelling.

Purpose and effectiveness

High levels of fats called triglycerides in the blood (hypertriglyceridemia). Research shows that taking a prescription drug called Vascepa that contains pure EPA can help lower triglyceride levels by 33% in people with very high triglyceride levels. This prescription product also reduces triglyceride levels by about 22 percent and cholesterol levels by 6 percent for most people who take cholesterol-lowering drugs called statins and whose triglyceride levels remain high. Taking this prescription drug also reduces the risk of major heart-related adverse events by about 25 percent in people who take statins and have persistently elevated triglyceride levels and other heart-related risk factors.

High levels of blood fats are called triglycerides (hypertriglyceridemia). Research shows that taking specific products containing eicosapentaenoic acid ethyl, eicosapentaenoic acid (made by Amarin and Vascepa) by mouth along with dieting and cholesterol-lowering drugs called "statins" reduces the risk in people with very High triglyceride levels. It may also improve cholesterol levels. This product is FDA approved for use in adults with very high triglyceride levels.

Heart disease (cardiovascular disease). Studies show that for people with high triglycerides, heart disease, or a high risk for heart disease, taking a prescription drug called Vascepa may reduce complications such as heart attacks and strokes.
depression. Research shows that taking pure EPA or fish oil containing at least 60% EPA can reduce symptoms of depression. It may work best when used with antidepressants.
heart attack. After a heart attack, people may have a procedure called percutaneous coronary intervention (PCI) to improve blood flow to the heart. Taking EPA by mouth along with medications called "statins" within 24 hours of PCI reduces the risk of heart-related adverse events, such as irregular heart beats (arrhythmias) or death after the procedure. Additionally, taking EPA and "statins" by mouth before undergoing PCI to treat chest pain may reduce the risk of a heart attack after the procedure.

side effect

When taken orally

When taken as a prescription product or as fish oil, EPA is safe for most adults. It has been used safely in research studies for up to 7 years. Most side effects are mild and may include nausea, diarrhea, upper abdominal discomfort, or burping. Taking EPA with a meal often reduces these side effects. EPA is probably safe when taken as part of algae oil (algae oil) for up to 12 weeks. But people should limit their intake of EPA and other omega-3 fatty acids to 3 grams per day, and should not consume more than 2 grams per day from dietary supplements unless approved by their healthcare provider. Doses of more than 3 grams of EPA and other omega-3 fatty acids per day may be unsafe. Consuming more than 3 grams of omega-3 fatty acids per day may slow blood clotting and may increase the chance of bleeding.

When given by IV

EPA is likely safe for most people when given by IV under the supervision of a healthcare provider. It is generally well tolerated.

Special notes and warnings

Pregnancy and breastfeeding

There is not enough reliable information to know whether EPA is safe to use during pregnancy or breastfeeding. Stay on the safe side and avoid using more than the serving size.

irregular heartbeat

For people with a history of irregular heartbeats, EPA may further increase the risk of irregular heartbeats. If you have a heart rhythm disorder, talk to your healthcare provider before starting taking EPA.

aspirin sensitivity

If you are sensitive to aspirin, EPA may affect your breathing.

interactive

Be careful with this combination

High blood pressure medications (antihypertensive drugs) interact with eicosapentaenoic acid (EPA)

Using EPA with medications that lower blood pressure may increase the effects of these medications and may lower blood pressure excessively.
Some medications to treat high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), amlodipine (Norvasc), hydrochlorothiazide (HydroDIURIL), Furosemide (Lasix), etc.

Drugs that slow blood clotting (anticoagulants/antiplatelet drugs) interact with eicosapentaenoic acid (EPA)

EPA may slow blood clotting. Taking EPA along with medications that slow blood clotting may increase the chance of bruising and bleeding.
Some drugs that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naproxen, others), dalteparin ( Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), etc.

Review

All comments are moderated before being published

HealthyPIG Magazine

View all
什麼是「操縱者」?

什麼是「操縱者」?

操縱者,也可以說成「擅用手段的人」,「心機重的人」。操縱者利用欺騙、影響或者其他形式的心理操控來控制或影響他人,以達到自己的目標。他們的行為通常包含使用隱蔽、間接或偷偷摸摸的手法來獲得他們想要的東西,往往是以犧牲他人為代價。以下是一些常見的特徵和手段: 欺騙: 他們可能會說謊或扭曲事實來誤...
什麼是肌肉抽搐?你需要去看醫生嗎?

什麼是肌肉抽搐?你需要去看醫生嗎?

肌肉抽搐,也稱為肌束顫動,是指身體各部分出現不自主的肌肉收縮。以下是肌肉抽搐的原因、症狀及管理方法的詳細介紹: 肌肉抽搐的原因 壓力和焦慮 高水平的壓力和焦慮會導致肌肉緊張和抽搐。身體對壓力的反應會觸發神經系統,導致肌肉不自主地收縮。 疲勞 過度使用或劇烈運動後的肌肉疲勞會導致肌...
蘋果與牙齒健康:保護牙齒的小技巧

Apples and Dental Health: Tips to Protect Your Teeth

Apples are widely loved for their rich nutritional content and refreshing taste. However, apples' acidic and sugary content may also have an impact...
蘋果籽的毒性:它們真的有毒嗎?

Apple Seed Toxicity: Are They Really Poisonous?

Apple seeds contain cyanogenic glycosides, compounds that break down in the body to produce cyanide, which has raised concerns about the toxicity o...
有機蘋果與傳統蘋果:哪個更健康?

Organic apples vs. conventional apples: Which one is healthier?

Apple is one of the common fruits in our daily life, but when choosing, many people are confused whether to choose organic apples or traditional ap...
艾草:益處,營養,副作用,評論和推薦產品

Wormwood: Benefits, Nutrition, Side Effects, Reviews and Recommended Products

Highlights What is Artemisia? Background and history health benefits Instructions drug interactions Side effects and disad...
紅麴米:益處,營養,副作用,評論和推薦產品

Red Yeast Rice: Benefits, Nutrition, Side Effects, Reviews and Recommended Products

Highlights What is Red Yeast Rice? Background and history health benefits Instructions drug interactions Side effects and ...
什麼是草藥膏?

What is herbal ointment?

Highlights What is Herbal Salve? Background and history health benefits Instructions drug interactions Side effects and di...
蘆薈:益處,營養,副作用,評論和推薦產品

Aloe Vera: Benefits, Nutrition, Side Effects, Reviews and Recommended Products

Highlights What is Aloe Vera? Background and history health benefits Instructions drug interactions Side effects and disad...