Indole-3-carbinol

Indole-3-carbinol (I3C, C9H9NO) is a chemical found in vegetables such as broccoli, Brussels sprouts, cabbage, kale, cauliflower, kale, mustard greens, radish and rutabaga. substance. It can also be produced in the laboratory.

Indole-3-carbinol is used to prevent breast, colon, and other types of cancer. The National Institutes of Health (NIH) has reviewed indole-3-carbinol as a possible cancer preventive agent and is currently funding clinical studies to prevent breast cancer.

Indole-3-carbinol is also used to treat fibromyalgia, viral tumors within the vocal cords (laryngeal papillomatosis), viral tumors within the respiratory tract (respiratory papillomatosis), and abnormal cell growth in the cervix (cervix dysplasia), and systemic lupus erythematosus (SLE). Some people use indole-3-carbinol to balance hormone levels, "detoxify" the gut and liver, and support the immune system.

How does it work?

Researchers are interested in indole-3-carbinol for preventing cancer, specifically breast, cervical, endometrial, and colorectal cancer. Their reasoning is that a diet high in fruits and vegetables can reduce the risk of cancer. Researchers suspect indole-3-carbinol is one of several plant compounds that may protect against cancer.

Might work...

• Abnormal development and growth of cervical cells (cervical dysplasia) .

There is insufficient evidence to assess effectiveness

• Respiratory papillomatosis . There is some evidence that long-term use of indole-3-carbinol may reduce tumor (papilloma) growth in people with recurrent respiratory papillomatosis.
• laryngeal mastoidomatosis
• Prevent breast cancer
• colorectal cancer
• Fibromyalgia
• systemic lupus erythematosus
• hormonal imbalance
• other

3-Indolecarbinol and cancer

Research into the mechanisms by which indole-3-carbinol consumption affects cancer incidence has focused on its ability to alter estrogen metabolism and other cellular effects. Controlled studies were conducted on animals such as rats, mice and rainbow trout, where various controlled levels of carcinogens and indole-3-carbinol were introduced into their daily diets. Results showed that indole-3-carbinol caused a dose-related reduction in tumor susceptibility (inferred by a reduction in aflatoxin-DNA binding). In 1989, the first direct evidence showed that a natural anticancer agent (3-indole-carbinol) found in the human diet had pure anti-initiating activity.

Indole-3-carbinol induces G1 growth arrest in human germline cancer cells. This may be relevant to the prevention and treatment of cancer because the G1 phase of cell growth occurs early in the cell's life cycle, and for most cells, this is the primary phase of the cell cycle in their life cycle. The G1 phase is marked by the synthesis of various enzymes required for the next ("S") phase, including enzymes required for DNA replication.

Overuse of indole-3-carbinol supplements for cancer prevention may be unwise, as hormonal balance should be tested (via a simple blood test) before regular consumption. Caution is recommended as it can affect estrogen levels (estrogen has a significant impact on brain function).

When combined with aflatoxin B1, it promotes liver cancer and reduces metastasis in trout.

melanoma

Indole-3-carbinol causes proliferative arrest and apoptosis in human melanoma cells. Studies have shown that microphthalmia-associated transcription factor (MITF-M), a major regulator of melanoma biology, is down-regulated by indole-3-carbinol, thereby inducing apoptosis. Research shows that indole-3-carbinol has anti-cancer properties by specifically targeting carcinogenic pathways. In two different studies using melanoma xenograft mouse models, they observed that subcutaneous injection of indole-3-carbinol significantly reduced tumor burden. The molecular mechanism underlying this antitumor effect was found to be through specific inhibition of the activity of oncogenic BRAFV600E in tumors harboring mutations. However, indole-3-carbinol did not induce any similar antiproliferative effects in tumors expressing wild-type BRAF. Furthermore, 3-indolecarbinol did not induce antiproliferation even in normal epidermal melanocytes, emphasizing the specificity and selectivity of its action. Kundu et al. It was further shown that inhibition of BRAF V600E activity by indole-3-carbinol leads to downstream signaling that downregulates MITF-M, leading to G1 cell cycle arrest, resulting in the observed antiproliferative effects.

One study showed that indole-3-carbinol directly interacts with NEDD41 to prevent PTEN ubiquitination and subsequent proteasomal degradation in PTEN-downregulated melanoma cells. This results in PTEN stabilization and inhibition of proliferation through downstream AKT signaling. Overall scientific evidence suggests that in melanoma, indole-3-carbinol specifically inhibits two of the most commonly associated driver mutation signaling pathways, leading to proliferation, a fact that could be used to design future therapies using indole-3-carbinol in human patients. Clinical Trials.

systemic lupus erythematosus

Indole-3-carbinol shifts estrogen metabolism toward less estrogenic metabolites. Systemic lupus erythematosus (SLE, or lupus) is an autoimmune disease related to estrogen. In a study using mice bred to have lupus, one group was fed indole-3-carbinol while another group was fed a standard mouse diet; Lifespan of the group fed the indole-3-carbinol diet longer and with fewer signs of disease.

Another study of lupus-prone mice showed that the mechanism by which indole-3-carbinol improved their disease was due to a sequential blockade of B- and T-cell development in these mice. Arrested maturation results in decreased autoantibody production and is thought to be an important component of the etiology of lupus. Furthermore, I3C supplementation in disease-prone mice normalized their T cell function.

Women with lupus can exhibit metabolic responses to indole-3-carbinol and may also benefit from its antiestrogenic effects. Clinical trials are currently underway to determine the efficacy of using indole-3-carbinol to treat human lupus patients.

When used in amounts commonly found in the diet, 3-indolecarbinol is probably safe for most people. It appears to be safe for most people when used in medicinal doses under appropriate medical supervision. It can cause side effects such as rash and small increases in liver enzymes.

Pregnancy and Breastfeeding : If you are pregnant or breastfeeding, stick to amounts of indole-3-carbinol commonly found in your diet. Little is known about the safety of indole-3-carbinol when administered in large doses.

Hepatic-altering Drugs (Cytochrome P450 1A2 (CYP1A2) Substrates) Interaction Rating: Moderate Use this combination with caution. Please consult your healthcare provider.

Some medications can be broken down by changes in the liver. Indole-3-carbinol may increase how quickly the liver breaks down certain medications. Taking indole-3-carbinol with some drugs that are altered by the liver may make some drugs less effective. Before taking 3-indolecarbinol, talk to your healthcare provider if you take any medications that can be altered by the liver.

Some drugs that are altered by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexitil ), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig) wait.

Scientific research has studied the following doses:

oral :

• For the treatment of abnormal cells on the surface of the cervix (cervical dysplasia): Use 200-400 mg daily. However, 200 mg appears to be as effective as higher doses.